Solid Fraction Data and Its Importance in Pharmaceuticals

Dry granulation is used in the pharmaceutical industry to improve powder flow by increasing their granular particle size. This is accomplished by using a roller press, which can be configured for different granule size and quality.

Roller compaction has a significant effect on the properties of granules and their suitability for tablet production¹. The technique  involves pressing powders together under high pressure to produce larger granules. Two pressure rollers squeeze the powder to make a ribbon of material of uniform thickness and density, which is then passed through a low-shear mill. The method is used widely in drug manufacture to produce solid dosage forms of high quality.

The process

Regulating roller compaction is essential to control granule properties. Maintaining a uniform density across the ribbon allows granulates with a more uniform particle size to be produced. Altering limits, such as the feed-in speed of the powder, the speed of the roller itself and the nip angle of the rollers to the ribbon, also allows the granulates properties to be fine-tuned. In this way, the granules can then control other product properties such as porosity, flowability, homogeneity, compactability and compressibility in the final product. These factors are essential as they influence dissolution profiles, disintegration times, and hardness of the final solid dosage form.

Measuring density

To control roller compaction, accurate measurements are required for the granulate products. The relative density or Solid Fraction is a crucial control parameter that determines the optimal setting for speed, compression and nip angle in the roller compactor. Using Solid Fraction data allows consistency from batch to batch, as well as an end- product with the designed and desired performance. Accurate measurements of volume and density can be difficult to achieve as the material has an irregular structure as well as pores. Three different definitions of density of a porous material are required, each requiring different techniques for measurement².

• Absolute density is obtained when the volume measured excludes both the pores within particles and the spaces between particles in the bulk material. A gas pycnometer, is the fastest and most accurate technique to use as the helium used quickly and thoroughly fills the smallest pore spaces. This method can be used on solids of all shapes and sizes, and the technique is recognised as one of the most reliable for obtaining volume and density.

• Envelope or bulk density includes the pore spaces in the volume measurement. The method here makes use of a free-flowing dry powder as the displacing medium. Solid fraction can then be calculated by dividing the envelope density of the ribbon by the absolute density of the granule.

• T.A.P density is obtained from filling a container with the test material and vibrating it so that the particles settle into the best packing arrangement. The measurement depends upon particle size distribution and shape as well as the technique.

Density Measurement Technology

Micromeritics has two automated pycnometer instruments (GeoPyc and AccuPyc) to determine each of the three different types of density. The GeoPyc measures envelope density using Dry Flo, a quasi-fluid composed of small, rigid spheres with a high degree of flowability. The sample is placed in a bed of Dry Flo which is then agitated. The Dry Flo particles form an 'envelope' around the sample; and are designed to conform closely to the surface of the object but not invade its pore spaces. The GeoPyc 1365 uses an intelligent touch-screen for control and reporting functions, the instrument can also provide T.A.P density measurements³.

The AccuPyc pycnometer provides high speed and high precision absolute density measurements. This instrument has been designed to provide temperature stability and accurate temperature control for all temperature-sensitive samples. This is important because although gas pycnometry provides reliable density measurements, temperature can have a major effect on volume (expansion) and affect accurate density determination. The AccuPyc offers temperature stability and accurate temperature control from 4-60⁰C (adjustable by 0.1⁰C) and guarantees temperature stability to +/- 0.025⁰C.

Conclusion

Micromeritics gas pycnometers allow the, reliable and accurate, control of roller compaction processes. Each instrument is designed to provide the pharmaceutical scientist with the ability to measure a range of essential parameters and keep tight control over their compaction operations⁴.

References and Further Reading

1. sciencedirect.com
2. http://www.micromeritics.com Brochure.pdf
3. https://www.micromeritics.com/geopyc/
4. http://www.micromeritics.com

This information has been sourced, reviewed and adapted from materials provided by Micromeritics Instrument Corporation.

For more information on this source, please visit Micromeritics Instrument Corporation.