Mar 28 2007
Genevac have released a new application report that discusses an effective method, using an HT-Series centrifugal evaporator, for preparing weighable samples from difficult to dry HPLC purification fractions.
Today HPLC is probably the purification method of choice within the Pharmaceutical industry. However many pharmaceutical companies regularly encounter a significant number of samples that do not dry well post purification. Typically, these stubborn samples form a gum or oil that creates problems including accelerated sample degradation (due to residual solvent) and difficulty in accurate weight determination.
The report, compiled in conjunction with KuDOS Pharmaceuticals and AstraZeneca, describes a new sample drying methodology that produces friable 'fluffy' solids that are fully dried and readily weighable from over 90% of previously intractable samples.
The report concludes that using the new methodology previously difficult to dry samples are delivered in a totally dry, easy to manipulate format. By using the Genevac HT-Series centrifugal evaporator the need for the authors to use additional laboratory equipment, such as a freeze drier, was eliminated.