Mar 13 2008
Radleys (Saffron Walden, UK) have introduced a new option for their Lara Controlled Laboratory Reactor (CLR) system and bespoke Laboratory Reactors that offers chemists studying crystal morphology significant benefits.
Traditionally chemists have used video microscopy as their technique of choice for non-invasive monitoring of particle shape, shape and quantity in process. Radleys split jacket laboratory reactors, are now available incorporating a flat, optically clear window for use with video microscopy. The new innovation opens the way to accurate and sensitive particle characterisation enabling early stage evaluation and resolution of process issues, thereby reducing process costs and avoiding the need for repeat batches.
Set within a narrow, central non-jacketed section the optical window ensures that the clearest possible image is obtained as particles are not obscured by the depth of the thermofluid within the jacket or the extra glass wall. The flatness of the window also eliminates any distortion of the image associated with undertaking video microscopy through the usual curved vessel surface.
Traditionally, fixing a flat optical window has involved "cementing" which can either compromise the vessel's chemical resistance or prevent the vessel from being annealed to relieve the stress created during manufacture. Radleys proprietary method of construction allows complete annealing of the finished vessel after manufacture. The window is therefore guaranteed to be stress free and vessel strength or safety is not compromised. Distortion to the internal surface is also minimised preventing eddies (dead zones) forming close to the internal wall.
By stopping the flow of thermal fluid through the top half of the reactor, Radleys split-jacket reactors maintain a cooler internal surface than traditional reactor vessel designs. This technological advance reduces the incidence of crystalline deposits baking onto the inside of the vessel, above the surface of the liquid, improving yields and cutting down on time lost in cleaning between reactions.
Posted March 13th,2008