New Options for Monitoring and Controlling Granulation, Coating and Spray Drying

Two new options for the Parsum IPP-70 in-line particle size measurement probe, supplied by Malvern Instruments, are designed to simplify regulatory compliance for pharmaceutical applications. The Parsum IPP-70 provides real-time particle size analysis, and is used in pharmaceutical manufacturing to monitor and control granulation, coating and spray drying processes.

Option 1 allows for the provision of Installation/Operational Qualification (IQ/OQ) documentation together with a verification kit for checking measurement accuracy. Option 2 offers a unit with highly polished contact surfaces, and includes material traceability documentation. The options are complementary and can be specified either separately or in combination.

The Parsum IPP-70 delivers size and velocity measurement for particles, granules and pellets from 50 to 6000 microns in diameter. Light and compact, it can be used to monitor gravity fed, pneumatically conveyed and fluidized streams. It is inserted directly into a process line or unit, and is easily integrated with existing systems for automated control. An intrinsically safe version is also available (IPP-70-SE).

The verification kit supplied with Option 1, when used with new software

(version 7.1), allows calibration of the whole measurement system – both probe and measurement PC. Calibration is achieved by measuring the diameter of three pins, of certified dimension, mounted on a rotating disc. Option 2 is particularly suitable for fouling duties and/or applications requiring high levels of hygiene.

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