Synthetic Sealant Gel Plugs Miniscule Leaks in Spinal Surgical Wounds

A new FDA-approved sealant gel was found effective in sealing spinal wounds following spinal surgery.

In a national multicenter study led by UC Davis Spine Center researchers, the gel created an effective watertight seal for closure of the surgical wounds. The randomized, 158-patient study was conducted at 24 centers across the US. The PEG hydrogel spinal sealant was given to 102 patients, while the remaining patients received standard care. Fibrin glue and additional sutures were provided to close the dura for patients under standard care. The "Valsalva maneuver" was used to determine the effectiveness of the seal. It was found that the PEG sealant provided a higher rate of closure.

The PEG sealant is a polyethylene glycol substance that can close very small leaks in the dura, the sheath that envelops the spinal cord. The sheath is located in the spinal column and contains cerebrospinal fluid in which the spinal cord floats. Any leakage may lead to serious infections. The sealant enables easy repairing of leaks in the spine. When the PEG gel makes body contact, it solidifies and forms a watertight seal. As the sealant is synthetic, it prevents risk of disease transmission.