Asynt | Synthesis of Squaric Acid Monoamides as Building Blocks for Drug Discovery

Chemists from the Wren Group at Kingston University (UK) have formed a collaborative relationship with Asynt Ltd & Key Organics, enabling them to create a novel synthetic compound library. Chemists from the University, Dr Stephen P. Wren, Professor Adam Le Gresley and PhD candidate Nathan Long, have built an initial synthetic compound library which is comprised of 28 anilino and benzylamino monosquarate-amide squaric acid derivatives designed as bioisosteric replacements for the omnipresent carboxylic acid moiety. These have been used to demonstrate the potential for the generation of additional novel compounds as compounds in this class can act as substrates in further chemical transformations. The compounds can be supplied in various formats to enrich worldwide drug discovery programs. Read the article in full via https://www.asynt.com/press-releases/... Contact [email protected] for further information or to discuss a possible collaboration.

Run Time: 1:49mins

Video Credit: Asynt