Litesizer DIF 500 provides sophisticated particle sizing from 10 nm to 3.5 mm, based on nearly 60 years of laser diffraction experience. This laser diffraction particle size analyzer has a best-in-class optical setup, powerful 10 mW and 25 mW lasers, and the market's greatest range of recorded diffraction angles (0.01°-170°).
Litesizer DIF 500
- Measure samples ranging from 0.01 µm to 3,500 µm
- Switch from liquid to dry dispersion in just one move
- Kalliope software: No training is necessary, dedicated QC mode
- Reliable outcomes, even in tough situations
The Kalliope software simplifies particle size analysis and requires no extensive training; measurements begin with three clicks. The Quick-Click method simplifies switching between dispersion units, reducing errors. Safety features for both liquid and dry dispersion provide easy and secure operation.
The sturdy metal enclosure and isolated optical bench assure dependability in every setting, from severe locations to high-tech laboratories.
This is next-generation laser diffraction technology, built on a pioneering tradition- Litesizer DIF 500: From First to Best.
Key Features
On Quality, We Lead the Way

Image Credit: Anton Paar GmbH
Litesizer DIF’s superior manufacturing makes it the ideal instrument for particle analysis. Its high-quality equipment enables the instrument to gather excellent raw data. With just one analyzer and no additional funding, customers may measure various samples with particle sizes ranging from 0.01 µm to 3500 µm with this laser diffraction particle size analyzer.
Kalliope: The Benchmark Software for Particle Sizing

Image Credit: Anton Paar GmbH
Due to its one-page workflow, users can get started with Kalliope right away. This workflow includes specifying parameters and obtaining and working with results. The QC mode provides consistent, dependable measurement data by locking sensitive settings and adjusting user management.
The QC mode instrument provides clear feedback if the product falls within the specified bounds. This means that new users need minimal training and only need to make three clicks. Kalliope also complies with the US FDA's 21 CFR Part 11 by offering a pharmaceutical option that includes data security features, user management, and audit trails.
Efficient Dispersion, Maximum Safety

Image Credit: Anton Paar GmbH
The Litesizer DIF's Quick-Click function links the dispersion units with a single move, eliminating the need for cables, tubes, or pipes. When adding the sample, the obscuration level indication allows users to monitor the sample amount as they add it, ensuring they receive the correct amount from the start.
Dispersion units are developed with safety in mind. The Dry Jet dispersion unit includes a suction check and a built-in dust cover to reduce the possibility of powder distribution. Furthermore, the Liquid Flow dispersion unit automatically checks for enough liquid before sonication, reducing overheating.
Particle Sizing in Any Environment

Image Credit: Anton Paar GmbH
Anton Paar's Litesizer DIF is ideal for heavy industry. It is built of high-quality materials both inside and out. A sturdy metal housing protects the optical elements. The Litesizer DIF is designed to withstand tough environments: no dust or powder can reach the instrument’s optical bench, and the inside is insulated from direct vibrations at the production site. All of this means lower maintenance and repair costs.
Less Investment, Saved Bench Space – Compatibility Across the Board

Image Credit: Anton Paar GmbH
The compatibility of dispersion units between Anton Paar's Litesizer DIA and Litesizer DIF devices minimizes investment costs and laboratory space requirements. Furthermore, all Litesizer instruments can be operated from a single PC running the Kalliope software.
Technical Specifications
Source: Anton Paar GmbH
. |
. |
Measurement principle |
Laser Diffraction (Mie and Fraunhofer scattering) |
Measurement range |
0.01 μm – 3500 μm |
Size classes |
144 (user adjustable) |
Accuracy* |
better than ± 0.5 % variation+ |
Repeatability |
better than ± 0.5 % variation+ |
Reproducibility** |
better than ± 1 % variation+ |
Possible measurement duration |
<10 sec |
Data acquisition rate |
16 kHz |
LIGHT SOURCE 1 |
|
Type |
Fiber-coupled laser diode |
Optical arrangement |
Reverse Fourier |
Wave length |
830 nm, infrared |
Power |
10 mW |
Laser class |
Class 1 (IEC60825-1) |
LIGHT SOURCE 2 |
|
Type L |
Laser diode |
Optical arrangement |
Tilted relative to IR laser |
Wave length |
450 nm, blue |
Power |
25 mW |
Laser class |
Class 1 (IEC60825-1) |
DETECTORS |
|
Type |
Log-spaced photodiode array and single diodes for side and back-scattering |
Angular range |
0.01° to 170° |
Focal length |
300 mm |
Alignment |
automatic |
INSTRUMENT SIZE |
|
Dimensions*** |
400 mm x 790 mm x 290 mm (H x W x D) |
Weight*** |
42.3 kg (93.2 lb) |
Power supply |
100 V to 240 V ±10 %, 50/60 Hz |
OPERATING CONDITIONS |
|
Temperature |
10 °C to 30 ºC |
Humidity |
35 % to 80 % non-condensing |
IP rating |
IP 41 |
COMPLIANT WITH |
|
Standards |
ISO 13320:2020, USP 429, ASTM B822 – 20, ASTM D4464 - 15(2020), ASTM E2316 - 14(2019) |
+ Sample and preparation dependent. Defined for liquid dispersion measurements.
* Defined for a monomodal latex standard and accounting for manufacturer's uncertainty of standard size.
** Defined for D50 of a polydisperse standard.
*** without PC and dispersion units